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EACON 2020

EurAsian Conference on Nanophotonics

April 6 – 9, 2020 / Jena, Germany

Kien-Voon Kong

Department of Chemistry, National Taiwan University, Taipei, Taiwan

Direct Observation of Reaction Intermediates of Metal-based Therapeutic Agents in Single Living Cell Using TERS

Metal-based anti-proliferative agents hold significant clinical and translational potential in cancer therapy. Direct detection of their intermediates in living cells is of paramount importance to unravel their anti-proliferative action, a pivotal factor leading to designing more effective chemotherapy drugs and chemical strategies to circumvent specific drug resistance mechanisms. This study demonstrates, for the first time, the power of tip-enhanced Raman scattering (TERS) to directly detect e transformation of ferrocenyl-based anti-proliferative agent in single living cell. Distinct vibrational features are observed for the formation of oxidized species in a cell and reacts with cellular nucleophiles. DFT calculations show that the observed vibrational mode changes are resultant of the different configuration of ferrocenyl-related modes. These results provide a better understanding of the ferrocenyl-based medicine for developing more advanced metal-based therapy agents.

  1. A dual signal amplification nanosensor based on SERS technology for detection of tumor-related DNA. Chemical communications 2019, 55 (11), 1548-1551
  2. Metal Carbonyls for the Biointerference-Free Ratiometric SERS-based Assay for Cell-Free Circulating DNA of Epstein-Barr Virus in Blood. Analytical chemistry, 2018, 90(12),7139-7147.
  3. Optical Interference-Free Surface-Enhanced Raman Scattering CO-Nanotags for Logical Multiplex Detection of Vascular Disease-Related Biomarkers. ACS Nano, 2017, 3, 3365-3375.

Further Talks

Andrea Csáki

Microfludic Synthesis of plasmonic Nanoparticles for Sensing Applications

Andrey Turchanin

Controlled growth of transition metal dichalcogenide monolayers for applications in nanoelectronic and nanophotonic devices

Chi Chen

Near Field Spectroscopic Imaging: from Hard to Soft Materials

Chi-How Peng

Cobalt mediated controlled/living radical polymerization: from mechanism understanding to materials application

Chun-Hong Kuo

Bridging Energy and Chemistry via Nanoarchitectonic Engineering at Atomic Scale

Falk Eilenberger

Integration of two-dimensional materials in optical systems for nonlinear optics, sensing, and single photon sources

Frank Setzpfandt

Nonlinear frequency conversion in nanostructured optical systems for application in quantum photonics

Heng-Liang Wu

Controlling the Oxidation State of Cu Electrode and Reaction Intermediates for Electrochemical CO2 Reduction to Ethylene

Kien-Voon Kong

Direct Observation of Reaction Intermediates of Metal-based Therapeutic Agents in Single Living Cell Using TERS

Maria Wächtler

Quantum confined semiconductor nanostructures in light-driven catalysis

Martin Presselt

Supramolecular Control of Optical and Electronical Properties of Two-Dimensional Dye Layers

Po-Chiao Lin

New Environment Sensitive Fluorophores with Color-Tailored Emission: In Vivo Monitoring of Carbonic Anhydrases Expression on Growth of Larval Zebrafish

Shangjr (Felix) Gwo

Plasmonic Metasurface-Enhanced Linear and Nonlinear Processes in Two-Dimensional Semiconductors

Ta-Jen Yen

Empowering Bilayer MoS2 by Engineered Plasmonic Nanostructures for Optoelectronic Applications

Tiow-Gan Ong

Carbodicarbene, Carbogenic Maverick, Not a Moderate!

Volker Deckert

Plasmon Enhanced Probe Spectroscopies – Structural Investigation of Nanoscale Objects

Yi-Tsu Chan

Molecular self-assembly methodology for rational construction of metallosupramolecules with high structural complexity

Yian Tai

Toward a universal polymeric material for electrode buffer layers in organic optoelectronics

Yu-Chieh Cheng

Kirigami-based soft robots with light-responsive properties

Yu-Jung Lu

Controlling Light-matter Interactions at Nanoscale with Plasmonics: From Spontaneous Emission to Lasing